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When trees are grown in Southeast Asia the levels tend to be higher but when grown elsewhere (even in greenhouses) the levels tend to be low or non-existent. The chemical structure of mitragynines incorporate the nucleus of the tryptamine and these may be responsible for the molecules which are observed in the serotonin and adrenergic systems. In mitragynine the phenolic methyl ether is considered to be stronger in analgesic paradigms according to some studies. In southern Thailand kratom chewers generally start best way to make kratom tea at around the age of 25 and many continue to chew the leaves for the rest of their lives.

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